![]() ![]() The mRNA levels of DUSP4, DUSP5, DUSP6, DUSP7, and DUSP14 in peripheral T cells were significantly higher in AS group than those of healthy controls (all p < 0.05), while DUSP22 (also named JKAP) mRNA levels were significantly lower in AS group than healthy controls ( p < 0.001). Finally, we investigated whether the characteristics of AS are developed in DUSP-knockout mice. Associations of gene expression of 23 DUSPs in peripheral T cells with inflammatory cytokine gene expression and disease activity of AS were analyzed. ![]() Sixty AS patients and 45 healthy controls were enrolled in this study. ![]() The aim of this study was to investigate the potential roles of DUSPs in ankylosing spondylitis (AS). Dual-specificity phosphatases (DUSPs) can dephosphorylate both tyrosine and serine/threonine residues of their substrates and regulate T cell-mediated immunity and autoimmunity. ![]()
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